Prediction and QSAR analysis of toxicity to Photobacterium phosphoreum for a group of heterocyclic nitrogen compounds.

Heterocyclic nitrogen compounds are extensively used as intermediates in the manufacture of pesticides and herbicides, while their toxicity has been little reported (Chen et al, 1997). In this paper, we report the toxicity of 14 heterocyclic nitrogen compounds to Photobacterium phosphoreum measured by Microtox® test which has been proposed as a cost-effective prescreening procedure to eliminate the relatively more innocuous chemicals from testing programs for toxicity of pollutants and is widely used in environmental analytical chemistry (Kamlet et al, 1986).